{
 "model_id": "unm-longcovid",
 "version": "1.2.0",
 "status": "research",
 "target": {
  "label": "Future Long COVID diagnosis code",
  "definition": "First ICD-10-CM U09.9 code 91-455 days after the first documented COVID-19 diagnosis",
  "population": "Adults with documented COVID-19 and no Long COVID code by day 90",
  "landmark_days": 90,
  "horizon_days": [
   91,
   455
  ]
 },
 "index_event": {
  "condition_codes": {
   "icd10cm": [
    "U07.1"
   ]
  },
  "earliest_date": "2021-07-02",
  "use_positive_tests": false,
  "positive_test_loinc": [
   "94500-6",
   "94309-2",
   "94534-5",
   "94558-4",
   "95209-3"
  ],
  "rule": "first U07.1 Condition dated on or after index_event.earliest_date (as in training) and on or before the scoring date; positive tests only if use_positive_tests"
 },
 "exclusion": {
  "condition_codes": {
   "icd10cm": [
    "U09.9"
   ],
   "snomed": [
    "1119303003",
    "1119304009",
    "1325161000000102"
   ]
  }
 },
 "windows": {
  "W0": [
   -365,
   -91
  ],
  "W1": [
   -90,
   -1
  ],
  "W2": [
   0,
   30
  ],
  "W3": [
   31,
   90
  ]
 },
 "features": [
  {
   "id": "age_18_39",
   "kind": "age_band",
   "min": 18,
   "max": 39,
   "group": "Demographics",
   "label": "Age 18-39",
   "weight": -0.247895
  },
  {
   "id": "age_40_49",
   "kind": "age_band",
   "min": 40,
   "max": 49,
   "group": "Demographics",
   "label": "Age 40-49",
   "weight": -0.068725
  },
  {
   "id": "age_50_59",
   "kind": "age_band",
   "min": 50,
   "max": 59,
   "group": "Demographics",
   "label": "Age 50-59",
   "weight": -0.038744
  },
  {
   "id": "age_60_69",
   "kind": "age_band",
   "min": 60,
   "max": 69,
   "group": "Demographics",
   "label": "Age 60-69",
   "weight": 0.270792
  },
  {
   "id": "age_70p",
   "kind": "age_band",
   "min": 70,
   "max": 200,
   "group": "Demographics",
   "label": "Age 70+",
   "weight": -0.21015
  },
  {
   "id": "sex_female",
   "kind": "sex",
   "value": "female",
   "group": "Demographics",
   "label": "Female",
   "weight": 0.207423
  },
  {
   "id": "sym_dyspnea",
   "label": "New: shortness of breath",
   "group": "New symptoms",
   "kind": "new_onset",
   "resource": "Condition",
   "codes": {
    "icd10cm_prefix": [
     "R060"
    ]
   },
   "present_in": [
    "W2",
    "W3"
   ],
   "absent_in": [
    "W0",
    "W1"
   ],
   "weight": 0.776553
  },
  {
   "id": "sym_cough",
   "label": "New: cough",
   "group": "New symptoms",
   "kind": "new_onset",
   "resource": "Condition",
   "codes": {
    "icd10cm_prefix": [
     "R05"
    ]
   },
   "present_in": [
    "W2",
    "W3"
   ],
   "absent_in": [
    "W0",
    "W1"
   ],
   "weight": 0.562928
  },
  {
   "id": "sym_chest_pain",
   "label": "New: chest pain",
   "group": "New symptoms",
   "kind": "new_onset",
   "resource": "Condition",
   "codes": {
    "icd10cm_prefix": [
     "R07"
    ]
   },
   "present_in": [
    "W2",
    "W3"
   ],
   "absent_in": [
    "W0",
    "W1"
   ],
   "weight": 0.830356
  },
  {
   "id": "sym_msk_pain",
   "label": "New: muscle or joint pain",
   "group": "New symptoms",
   "kind": "new_onset",
   "resource": "Condition",
   "codes": {
    "icd10cm_prefix": [
     "M791",
     "M255",
     "M796",
     "M797"
    ]
   },
   "present_in": [
    "W2",
    "W3"
   ],
   "absent_in": [
    "W0",
    "W1"
   ],
   "weight": 0.700514
  },
  {
   "id": "sym_count_ge2",
   "label": "Two or more new symptom types",
   "group": "New symptoms",
   "kind": "derived_count_ge",
   "of_group": "New symptoms",
   "threshold": 2,
   "weight": 0.683606
  },
  {
   "id": "hx_asthma",
   "label": "History: asthma",
   "group": "Prior conditions",
   "kind": "any",
   "resource": "Condition",
   "codes": {
    "icd10cm_prefix": [
     "J45"
    ]
   },
   "present_in": [
    "W0",
    "W1"
   ],
   "weight": 0.440153
  },
  {
   "id": "hx_copd",
   "label": "History: COPD",
   "group": "Prior conditions",
   "kind": "any",
   "resource": "Condition",
   "codes": {
    "icd10cm_prefix": [
     "J44"
    ]
   },
   "present_in": [
    "W0",
    "W1"
   ],
   "weight": 0.658129
  },
  {
   "id": "hx_diabetes",
   "label": "History: diabetes",
   "group": "Prior conditions",
   "kind": "any",
   "resource": "Condition",
   "codes": {
    "icd10cm_prefix": [
     "E10",
     "E11"
    ]
   },
   "present_in": [
    "W0",
    "W1"
   ],
   "weight": 0.381039
  },
  {
   "id": "hx_obesity",
   "label": "History: obesity",
   "group": "Prior conditions",
   "kind": "any",
   "resource": "Condition",
   "codes": {
    "icd10cm_prefix": [
     "E66",
     "Z683",
     "Z684"
    ]
   },
   "present_in": [
    "W0",
    "W1"
   ],
   "weight": 0.422637
  },
  {
   "id": "hx_hypertension",
   "label": "History: hypertension",
   "group": "Prior conditions",
   "kind": "any",
   "resource": "Condition",
   "codes": {
    "icd10cm_prefix": [
     "I10"
    ]
   },
   "present_in": [
    "W0",
    "W1"
   ],
   "weight": 0.239287
  },
  {
   "id": "hx_depression",
   "label": "History: depression",
   "group": "Prior conditions",
   "kind": "any",
   "resource": "Condition",
   "codes": {
    "icd10cm_prefix": [
     "F32",
     "F33"
    ]
   },
   "present_in": [
    "W0",
    "W1"
   ],
   "weight": 0.668623
  },
  {
   "id": "hx_anxiety",
   "label": "History: anxiety",
   "group": "Prior conditions",
   "kind": "any",
   "resource": "Condition",
   "codes": {
    "icd10cm_prefix": [
     "F41"
    ]
   },
   "present_in": [
    "W0",
    "W1"
   ],
   "weight": 0.461967
  },
  {
   "id": "hx_migraine",
   "label": "History: migraine",
   "group": "Prior conditions",
   "kind": "any",
   "resource": "Condition",
   "codes": {
    "icd10cm_prefix": [
     "G43"
    ]
   },
   "present_in": [
    "W0",
    "W1"
   ],
   "weight": 0.267112
  },
  {
   "id": "hx_chronic_pain",
   "label": "History: chronic pain",
   "group": "Prior conditions",
   "kind": "any",
   "resource": "Condition",
   "codes": {
    "icd10cm_prefix": [
     "G89"
    ]
   },
   "present_in": [
    "W0",
    "W1"
   ],
   "weight": 0.462634
  },
  {
   "id": "hx_sleep_apnea",
   "label": "History: sleep apnea",
   "group": "Prior conditions",
   "kind": "any",
   "resource": "Condition",
   "codes": {
    "icd10cm_prefix": [
     "G4733"
    ]
   },
   "present_in": [
    "W0",
    "W1"
   ],
   "weight": 0.754842
  },
  {
   "id": "hx_autoimmune",
   "label": "History: autoimmune",
   "group": "Prior conditions",
   "kind": "any",
   "resource": "Condition",
   "codes": {
    "icd10cm_prefix": [
     "M05",
     "M06",
     "M32",
     "L40",
     "K50",
     "K51",
     "M45"
    ]
   },
   "present_in": [
    "W0",
    "W1"
   ],
   "weight": 0.353891
  },
  {
   "id": "hx_hypothyroid",
   "label": "History: hypothyroid",
   "group": "Prior conditions",
   "kind": "any",
   "resource": "Condition",
   "codes": {
    "icd10cm_prefix": [
     "E03"
    ]
   },
   "present_in": [
    "W0",
    "W1"
   ],
   "weight": 0.239087
  },
  {
   "id": "hx_heart_disease",
   "label": "History: heart disease",
   "group": "Prior conditions",
   "kind": "any",
   "resource": "Condition",
   "codes": {
    "icd10cm_prefix": [
     "I25",
     "I50"
    ]
   },
   "present_in": [
    "W0",
    "W1"
   ],
   "weight": 0.065752
  },
  {
   "id": "acute_inpatient",
   "label": "Hospitalized around the COVID diagnosis",
   "group": "Acute illness",
   "kind": "encounter_any",
   "window": [
    -3,
    30
   ],
   "encounter_class": [
    "IMP"
   ],
   "weight": 0.566488
  },
  {
   "id": "acute_ed",
   "label": "Emergency visit in the first month",
   "group": "Acute illness",
   "kind": "encounter_any",
   "window": [
    0,
    30
   ],
   "encounter_class": [
    "EMER"
   ],
   "weight": 0.464286
  },
  {
   "id": "out_w0_ge4",
   "kind": "encounter_count_ge",
   "encounter_class": [
    "AMB"
   ],
   "windows": [
    "W0"
   ],
   "threshold": 4,
   "label": "4+ outpatient visits in the baseline year",
   "group": "Health care use",
   "weight": 0.268347
  },
  {
   "id": "out_w3_ge2",
   "kind": "encounter_count_ge",
   "encounter_class": [
    "AMB"
   ],
   "windows": [
    "W3"
   ],
   "threshold": 2,
   "label": "2+ outpatient visits in days 31-90",
   "group": "Health care use",
   "weight": 0.479927
  },
  {
   "id": "out_w3_ge4",
   "kind": "encounter_count_ge",
   "encounter_class": [
    "AMB"
   ],
   "windows": [
    "W3"
   ],
   "threshold": 4,
   "label": "4+ outpatient visits in days 31-90",
   "group": "Health care use",
   "weight": 0.623184
  },
  {
   "id": "ed_w3_any",
   "kind": "encounter_count_ge",
   "encounter_class": [
    "EMER"
   ],
   "windows": [
    "W3"
   ],
   "threshold": 1,
   "label": "Emergency visit in days 31-90",
   "group": "Health care use",
   "weight": 0.544081
  },
  {
   "id": "ip_w3_any",
   "kind": "encounter_count_ge",
   "encounter_class": [
    "IMP"
   ],
   "windows": [
    "W3"
   ],
   "threshold": 1,
   "label": "Hospital stay in days 31-90",
   "group": "Health care use",
   "weight": 0.627951
  },
  {
   "id": "visit_rate_up",
   "kind": "encounter_rate_ratio_ge",
   "encounter_class": [
    "AMB",
    "EMER"
   ],
   "numerator": "W3",
   "denominator": "W0",
   "threshold": 2.0,
   "label": "Visit rate after COVID at least double the baseline rate",
   "group": "Health care use",
   "weight": 0.083971
  },
  {
   "id": "test_chest_ct",
   "label": "Chest CT",
   "group": "Tests after COVID",
   "kind": "any",
   "resource": "Procedure",
   "codes": {
    "cpt": [
     "71250",
     "71260",
     "71270",
     "71271",
     "71275"
    ]
   },
   "present_in": [
    "W2",
    "W3"
   ],
   "weight": 1.100903
  },
  {
   "id": "test_chest_xray",
   "label": "Chest X-ray",
   "group": "Tests after COVID",
   "kind": "any",
   "resource": "Procedure",
   "codes": {
    "cpt": [
     "71045",
     "71046",
     "71047",
     "71048"
    ]
   },
   "present_in": [
    "W2",
    "W3"
   ],
   "weight": 0.588097
  },
  {
   "id": "lab_d_dimer",
   "label": "D-dimer test",
   "group": "Tests after COVID",
   "kind": "any",
   "resource": "Observation",
   "codes": {
    "loinc": [
     "15179-5",
     "29280-5",
     "38898-3",
     "42499-4",
     "42727-8",
     "48058-2",
     "48065-7",
     "48066-5",
     "48067-3",
     "55398-2",
     "71427-9",
     "91556-1"
    ]
   },
   "present_in": [
    "W2",
    "W3"
   ],
   "weight": 0.831808
  },
  {
   "id": "lab_troponin",
   "label": "Troponin test",
   "group": "Tests after COVID",
   "kind": "any",
   "resource": "Observation",
   "codes": {
    "loinc": [
     "101375-4",
     "101865-4",
     "101911-6",
     "101912-4",
     "101913-2",
     "101914-0",
     "101915-7",
     "101916-5",
     "101917-3",
     "101918-1",
     "10839-9",
     "33204-9",
     "42757-5",
     "48425-3",
     "48426-1",
     "49563-0",
     "6597-9",
     "6598-7",
     "67151-1",
     "76399-5",
     "89575-5",
     "89576-3",
     "89577-1",
     "89578-9",
     "89579-7"
    ]
   },
   "present_in": [
    "W2",
    "W3"
   ],
   "weight": 0.741017
  },
  {
   "id": "lab_natriuretic",
   "label": "BNP or NT-proBNP test",
   "group": "Tests after COVID",
   "kind": "any",
   "resource": "Observation",
   "codes": {
    "loinc": [
     "30934-4",
     "33762-6",
     "33763-4",
     "42637-9",
     "47092-2",
     "71425-3",
     "77621-1",
     "77622-9",
     "83107-3",
     "83108-1"
    ]
   },
   "present_in": [
    "W2",
    "W3"
   ],
   "weight": 0.544609
  },
  {
   "id": "lab_tsh",
   "label": "Thyroid (TSH) test",
   "group": "Tests after COVID",
   "kind": "any",
   "resource": "Observation",
   "codes": {
    "loinc": [
     "10516-3",
     "11033-8",
     "11579-0",
     "11580-8",
     "12932-0",
     "12933-8",
     "12934-6",
     "12935-3",
     "12936-1",
     "12937-9",
     "12938-7",
     "12939-5",
     "12940-3",
     "12941-1",
     "12942-9",
     "12943-7",
     "12944-5",
     "12945-2",
     "12946-0",
     "12947-8",
     "12948-6",
     "13869-3",
     "13871-9",
     "13897-4",
     "14255-4",
     "14919-5",
     "14997-1",
     "14998-9",
     "14999-7",
     "15000-3",
     "17786-5",
     "20452-9",
     "25789-9",
     "25990-3",
     "25991-1",
     "26998-5",
     "29316-7",
     "29317-5",
     "29574-1",
     "29575-8",
     "3015-5",
     "30151-5",
     "3016-3",
     "3018-9",
     "3019-7",
     "33258-5",
     "33259-3",
     "33260-1",
     "33261-9",
     "33269-2",
     "34054-7",
     "35134-6",
     "40397-2",
     "40398-0",
     "40399-8",
     "40400-4",
     "40401-2",
     "40673-6",
     "44935-5",
     "44936-3",
     "45173-2",
     "47947-7",
     "47948-5",
     "47949-3",
     "47950-1",
     "47951-9",
     "47952-7",
     "47953-5",
     "48077-2",
     "48700-9",
     "50533-9",
     "50534-7",
     "50535-4",
     "50536-2",
     "50537-0",
     "50538-8",
     "50539-6",
     "50540-4",
     "50541-2",
     "5384-3",
     "5385-0",
     "55362-8",
     "56594-5",
     "57416-0",
     "57854-2",
     "58833-5",
     "58834-3",
     "63363-6",
     "63364-4",
     "63365-1",
     "63366-9",
     "65360-0",
     "69561-9",
     "70096-3",
     "77623-7",
     "82659-4",
     "90801-2",
     "99078-8"
    ]
   },
   "present_in": [
    "W2",
    "W3"
   ],
   "weight": 0.447952
  },
  {
   "id": "lab_ferritin",
   "label": "Ferritin test",
   "group": "Tests after COVID",
   "kind": "any",
   "resource": "Observation",
   "codes": {
    "loinc": [
     "14723-1",
     "14724-9",
     "20567-4",
     "2276-4",
     "24373-3",
     "48141-6",
     "53048-5",
     "74807-9",
     "86914-9"
    ]
   },
   "present_in": [
    "W2",
    "W3"
   ],
   "weight": 0.529826
  },
  {
   "id": "lab_crp",
   "label": "C-reactive protein test",
   "group": "Tests after COVID",
   "kind": "any",
   "resource": "Observation",
   "codes": {
    "loinc": [
     "11039-5",
     "14634-0",
     "16503-5",
     "1988-5",
     "30522-7",
     "35648-5",
     "45062-7",
     "48421-2",
     "59182-6",
     "71426-1",
     "76485-2",
     "76486-0",
     "98987-1"
    ]
   },
   "present_in": [
    "W2",
    "W3"
   ],
   "weight": 0.753055
  },
  {
   "id": "lab_vitamin_d",
   "label": "Vitamin D test",
   "group": "Tests after COVID",
   "kind": "any",
   "resource": "Observation",
   "codes": {
    "loinc": [
     "14635-7",
     "1989-3",
     "46269-7",
     "49054-0",
     "55814-8",
     "57566-2",
     "57567-0",
     "57568-8",
     "57569-6",
     "62292-8",
     "68438-1",
     "72403-9",
     "72404-7",
     "72888-1",
     "83070-3",
     "83071-1",
     "86918-0",
     "94673-1",
     "94674-9",
     "95593-0",
     "95594-8",
     "95595-5"
    ]
   },
   "present_in": [
    "W2",
    "W3"
   ],
   "weight": 0.551808
  },
  {
   "id": "lab_b12",
   "label": "Vitamin B12 test",
   "group": "Tests after COVID",
   "kind": "any",
   "resource": "Observation",
   "codes": {
    "loinc": [
     "1460-5",
     "14685-2",
     "14733-0",
     "15052-4",
     "16695-9",
     "16696-7",
     "1888-7",
     "2132-9",
     "2169-1",
     "2171-7",
     "2440-6",
     "26916-7",
     "3029-6",
     "3031-2",
     "3032-0",
     "30904-7",
     "30905-4",
     "30906-2",
     "32341-0",
     "33766-7",
     "4203-6",
     "49264-5",
     "54376-9",
     "54377-7",
     "54378-5",
     "55850-2",
     "55881-7",
     "55882-5",
     "55883-3",
     "55884-1",
     "55885-8",
     "59211-3",
     "72157-1",
     "72158-9",
     "72160-5",
     "96297-7",
     "96805-7",
     "96809-9"
    ]
   },
   "present_in": [
    "W2",
    "W3"
   ],
   "weight": 0.608043
  },
  {
   "id": "rx_inhaler",
   "label": "New inhaler",
   "group": "New medications",
   "kind": "new_onset",
   "resource": "MedicationRequest",
   "codes": {
    "rxcui": [
     "102377",
     "102378",
     "102379",
     "102380",
     "102381",
     "103413",
     "103414",
     "103415",
     "103416",
     "103472",
     "103473",
     "1036806",
     "1036816",
     "1036891",
     "1036892",
     "1036897",
     "104501",
     "104502",
     "104504",
     "104505",
     "104506",
     "104514",
     "104531",
     "106787",
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  "fit": {
   "type": "logistic on binned training-split counts",
   "a": -3.9407481733184286,
   "b": 0.18952476047247507
  }
 },
 "risk_bands": [
  {
   "name": "Typical",
   "max_probability": 0.015474
  },
  {
   "name": "Elevated",
   "max_probability": 0.030948
  },
  {
   "name": "High",
   "max_probability": 1.0
  }
 ],
 "reference": {
  "cohort_base_rate": 0.010316
 },
 "provenance": {
  "data": "NIH All of Us Research Program, Registered Tier Dataset v9 (CDR R2025Q4R6)",
  "method": "nb_eb: fit outside the Researcher Workbench from dissemination-compliant summary counts (every released cell above 20, rounded to 10); no participant-level data or participant-trained model left Workbench",
  "open_data": [
   "CDC/NCHS Household Pulse Survey, Post-COVID Conditions (gsea-w83j)",
   "CMS Medicare Physician & Other Practitioners by Geography and Service, CY2024",
   "NLM RxNorm, LOINC, ICD-10-CM vocabularies"
  ],
  "validation_split_evaluation": {
   "auroc": 0.6736,
   "auprc": 0.0282,
   "held_out_people": "4680",
   "held_out_positives": "50",
   "participant_level_comparators": {
    "M2_elastic_net_logistic": 0.6804,
    "M4_pu_bagging": 0.6727
   },
   "note": "random 20% validation split (Task 36, seed 20260929); held-out-site AUROC of the frozen 41-feature pipeline: 0.659 (95% CI 0.576-0.722), results/aggregate/36/t17_site_performance.csv"
  },
  "features_note": "Condition features use ICD-10-CM codes from both condition_occurrence and observation for every predictor (Task 35; results/aggregate/35/t35_guard_summary.csv)"
 },
 "statement": "Research decision support. Surfaces chart patterns for clinician review. Not a diagnosis."
}